Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

A STAGE-STRUCTURED SI ECO-EPIDEMIOLOGICAL MODEL WITH TIME DELAY AND IMPULSIVE CONTROLLING*

This paper formulates a robust stage-structured SI eco-epidemiological model with periodic constant pulse releasing of infectious pests with pathogens. The authors show that the conditions for global attractivity of the ＇pest-eradication＇ periodic solution and permanence of the system depend on time delay, hence, the authors call it ＂profitless＂. Further, the authors present a pest management strategy in which the pest population is kept under the economic threshold level （ETL） when the pest population is uniformly persistent. By numerical analysis, the authors also show that constant maturation time delay for the susceptible pests and pulse releasing of the infectious pests can bring obvious effects on the dynamics of system.     

一类非线性规划问题的等价性证明

给出了非线性规划问题中目标函数单调变换前后的一个等价性证明.     

铝厂污水零排放研究

本文从水质方面分析了西南某铝厂污水零排放的可行性。为了实现污水零排放,对该铝厂东片区、氧化铝厂、热电厂三大污水处理系统进行改进。从现场试验监测及统计分析结果表明,改进后的处理系统处理的水质满足再生水水质指标要求,该铝厂污水零排放的实现创造了极大的经济和社会效益。     

Research on consistency measurement and weight estimation approach of hybrid uncertain comparison matrix

The consistency measurement and weight estimation approach of the hybrid uncertain comparison matrix in the analytic hierarchy process （AHP） are studied. First, the decision-making satisfaction membership function is defined based on the decision making＇s allowable error. Then, the weight model based on the maximal satisfactory consistency idea is suggested, and the consistency index is put forward. Moreover, the weight distributing value model is developed to solve the decision making misleading problem since the multioptimization solutions in the former model. Finally, the weights are ranked based on the possibility degree approach to obtain the ultimate order.     

序列模式挖掘的两种典型算法及比较

序列模式挖掘是数据挖掘的重要分支,GSP算法与PSP算法是序列模式挖掘中的两种典型算法。本文介绍了这两种算法并对其进行了分析与比较。     

一种基于段的基音检测算法

作为语音信号处理领域一项基本、关键的技术,基音检测在语音信号处理中扮演着重要的角色,一直是语音信号处理的一个研究热点.首先对传统的基于短时自相关函数法的基音检测进行了研究;在此基础上提出了一种能同时检测一段语音信号基音周期的方法,有效地克服了传统基音检测算法只能检测一帧语音信号基音的缺点.进行了实验仿真,结果表明通过去野点,中值平滑等后处理的基于段的基音检测算法比传统的基于帧的基音检测算法具有更好的抗噪性.     

文学的存在方式现象学

文学的存在方式是指文学赖以存在的整体结构。通过对文学创作活动(事件)、文学接受活动(事件)的现象学描述,建构了文学的存在方式———文学存在的四维整体结构和文学存在之主体间的交流结构,后两者共同组建着文学的存在整体。     

基于动态拓扑有领航者的智能群体群集运动控制

对具有二次积分动态的智能群体跟随领航者实现群集运动编队,提出了一个分散控制方法对智能群体进行分散控制。基于动态时变有领航者的网络拓扑,用图论模型表示智能体之间的相互作用及通信关系,运用推广的Lyapunov理论、微分包含及非平滑分析进行了稳定性分析,并得到所有智能体速度方向收敛到同一方向并与领航者保持一致;所有智能体速度大小收敛并与领航者相同;互连的智能体之间没有碰撞发生;所有智能体的人工势场函数被最小化等重要结论。给出了一个仿真实例,验证了该方法的有效性。